YK grade(I) Classification by LDA modelsa YK grade(II) Patients (Pathological diag.) LDA1 LDA2 LDA3 LDA4 (Molecular diag.) SCC129 1 + + + - 4C (↑↑↑)b SCC126 2 + + - - 3 (↑) SCC132 2 - - - - 1(↓) SCC131 3 + + - - 3 SCC133 3 + + - - 3 SCC127 3 + + - - 3 SCC139 3 + + - - 3 SCC137 3 + + - - 3 SCC134 3 + + + - 4C (↑) SCC138 3 + + - - 3 SCC125 3 + + + - 4C (↑) SCC130 4C# + + + - 4C SCC124 4C + + + - 4C Fidelity (%)c   77 85 77 100   aGray backgrownd denotes discrepancy between pathological and molecular diagnoses. bOne rank over (↑)/Under (↓)estimation compared with the pathologycal diagnosis. cFidelity to the pathological diagnosis. #After intensive examination, the pathological diagnosis has been corrected from grade 2 to 4C.

Table 4: Prediction of invasion status by LDA models in 13 test OSCC samples.