Figure 4: Effect of spleen NK cells isolated from healthy or TBM without and with Dox on the survival of MCA FS. The ratio of cultured MCA FS to NK cells is 1:1 (105 each). Healthy NK cells induced higher MCA FS cytotoxicity than NK cells obtained from TBM (*p<0.01). Dox at 0.5 μM and above enhanced significantly healthy NK cells induced MCA FS cytotoxicity (†p<0.05, p<0.01). However, the effect of higher concentrations of Dox (5 or 10 μM) on TBM NK cells induced MCA FS cytotoxicity was not significantly different than that of healthy NK cells.