Figure 4: Effect of Vandetanib on Apoptosis in RTE Cells. Primary RTE cells were treated with B[a]P alone or with five half - log concentrations (0.003, 0.01, 0.03, 0.1 and 0.3 µM ) of Vandetanib and harvested at 21 days for measuring apoptosis by the TUNEL assay. Two thousand cells/treatment group were scored to determine the apoptotic index (number of apoptotic cells / number of total cells × 100) and the data is expressed as fold apoptotic induction from B[a]P.