Figure 1: A and C, macroscopic clinical features of a basal cell carcinoma before and after topical dobesilate treatment for 12 weeks, respectively. In the pre-treatment biopsy, typical features of invasive BCC that disappear after 12 weeks of topical dobesilate application are readily observed by hematoxylin and eosin staining (Panel B vs. Panel D). Original magnification B-D (x200).