Figure 5: Case report 5: Evolution of skin lesions that appeared after two cycles of neo TPF. 5A: After two cycles of neo TPF: development of grade 1 skin toxicity. 5B: 4th week after radiotherapy treatment: development of grade 1 radiation dermatitis. 5C: 5th week of radiotherapy: worsening of the symptoms (grade 2 skin toxicity). A topical treatment was initiated. 5D: 7th week of radiotherapy: an oral antibiotic treatment was administered. 5E: 1st week after radiotherapy: worsening of the lesions. 5F: 2nd week after radiotherapy: initiation of treatment with collagenase ointment. 5G: 3rd week after radiotherapy: improvement of the lesions while receiving collagenase treatment 5H: 4th week after radiotherapy dermatitis: complete resolution of the lesions.