| Period |
From
(Myr ago) |
To
(Myr ago) |
Time range
(Myr) |
Origin of miRNA Genes |
Origin of miRNA gene families |
| Number |
Rate |
Number |
Rate |
| p<0.01 |
p<0.05 |
p<0.01 |
p<0.05 |
p<0.01 |
p<0.05 |
p<0.01 |
p<0.05 |
| 1 |
6.3 |
0 |
6.3 |
122 |
160 |
19.4 |
25.4 |
72 |
98 |
11.4 |
15.6 |
| 2 |
8.8 |
6.3 |
2.5 |
59 |
63 |
23.6 |
25.2 |
38 |
39 |
12.8 |
15.6 |
| 3 |
15.7 |
8.8 |
6.9 |
134 |
122 |
19.4 |
17.7 |
88 |
81 |
11.0 |
11.7 |
| 4 |
20.4 |
15.7 |
4.7 |
89 |
91 |
18.9 |
19.4 |
92 |
98 |
19.5 |
20.9 |
| 5 |
29.0 |
20.4 |
8.6 |
219 |
220 |
25.4 |
25.6 |
161 |
161 |
18.7 |
18.7 |
| 6 |
42.6 |
29.0 |
13.6 |
316 |
317 |
23.2 |
23.3 |
263 |
261 |
19.3 |
19.2 |
| 7 |
92.3 |
42.6 |
49.7 |
169 |
144 |
3.4 |
2.9 |
121 |
104 |
2.4 |
2.1 |
The numbers of human miRNA orthologues predicted at significance levels of p<0.01 and p<0.05 were shown for each evolutionary period of birth. The generation rate of miRNA genes per Myr was calculated based on the divergence time estimated by TimeTree [10]. |
