Cavernous angiomas are vascular lesions comprised of clusters of abnormally dilated blood vessels. These lesions can be found in the brain, spinal cord, and, rarely, in other areas of the body including the skin and retina. Cavernous malformations are dilated blood vessels that are characterized by multiple distended "caverns" of blood-filled vasculature through which the blood flows very slowly. Vessels of a cavernous malformation lesion have a tendency to leak because they lack the proper junctions between neighboring cells as well as the necessary structural support from smooth muscle and stretchable material (elastin). Leakage (bleeding) from these vascular lesions is the underlying cause of clinical symptoms associated with the illness. Cavernous malformations are primarily located in the brain, but can also be found in the spinal cord, on the skin, and more rarely in the retina.
Symptoms are highly variable among individuals; in some cases no symptoms may be present. However, when symptoms do manifest they often depend on the location of the angioma and on the strength of the angioma walls and their propensity for bleeding. Resesach is going on non-surgical treatmentTwo potential therapeutics, simvastatin and Fasudil, are currently being studied in cell and animal-based models of the illness.
Geographical analysis: 99,565 of the people were affected in Australia.