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Beta thalassemia or Cooley’s anemia is caused by mutations in the beta chain of the hemoglobin molecule. There is one beta chain gene on each 11th chromosome, for a total of two. How these genes are altered determines the specific type of beta thalassemia in a child. This form of thalassemia is usually so severe that it requires regular blood transfusions.
Cooley’s anemia is most often found in people who are of Mediterranean ancestry (Greek or Italian). Each child of two carrier parents is at 25 percent risk for the disease. A doctor who is trying to diagnose thalassemia will typically take a blood sample. It will be tested for anemia and for abnormal hemoglobin.
Clinical researchers working in avoiding spleen removal for Cooley's anemia sufferers, to find potential of Hepcidin hormone for anemic blood disorders, Finding different Gene therapy alternative to current cures for blood disorder β-thalassemia etc.
Cooley’s anemia effects approximately 1 in 272,000 or 0.00% or 1,000 people. In Argentina 1,079 from 293,655,405 people were affected from Cooley’s anemia.