alexa Creutzfeldt-Jakob disease | Australia | PDF | PPT| Case Reports | Symptoms | Treatment

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Creutzfeldt-Jakob Disease

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  • Creutzfeldt-Jakob disease

    Creutzfeldt–Jakob or CJD is a degenerative neurological disease that is incurable and invariably fatal. CJD is at times called a human form of mad cow disease. CJD is caused by an agent called a prion. Prions are misfolded proteins that replicate by converting their properly folded counterparts, in their host, to the same misfolded structure they possess. CJD causes the brain tissue to degenerate rapidly, and as the disease destroys the brain, the brain develops holes and the texture changes to resemble that of a kitchen sponge. The first symptom of CJD is rapidly progressive dementia, leading to memory loss, personality changes, and hallucinations. Other frequently occurring features include anxiety, depression, paranoia, obsessive-compulsive symptoms, and psychosis.
    The annual incidence of CJD in Australia is around 1 case per million, although it is speculated that this may well be higher as has been indicated from several international surveillance centres, where the annual incidence of 2 cases per million per year has been observed.

  • Creutzfeldt-Jakob disease

    No generally accepted treatment for CJD exists; the disease is invariably fatal and research continues. Amphotericin B and Doxorubicin have been investigated as potentially effective against CJD, but as yet there is no strong evidence that either drug is effective in stopping the disease. Further study has been taken with other medical drugs, but none are effective. However, drugs to reduce suffering do exist, and include valproate, an anticonvulsant agent, clonazepam and benzodiazepine, to reduce muscle jerks.
    The ongoing researches in Australia on Creutzfeldt–Jakob disease include: Creutzfeldt-Jakob disease surveillance in Australia, Electroencephalographic changes in sporadic Creutzfeldt-Jakob disease and correlation with clinical stages, Characterising the uncommon corticobasal syndrome presentation of sporadic Creutzfeldt-Jakob disease.

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