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Double Uterus

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  • Double uterus

    A double uterus, also known as a didelphys uterus, is a rare condition in which a woman has duplication of the uterus. Although the exact reason why this congenital abnormality develops is unknown, it represents a lack of fusion of early embryonic structures.

  • Double uterus

    Overall, about 1 in 80-90 births in Australia is a twin and of these about 30% are MZ(monozygotic or identical (MZ).

  • Double uterus

    Double uterus with no signs or symptoms, treatment is rarely needed. Surgery to unite a double uterus is rarely done ? although surgery may help you sustain a pregnancy if you have a partial division within your uterus and no other medical explanation for a previous pregnancy loss.

  • Double uterus

    On research it is found that , Although the exact cause is unknown, the developmental basis for having this condition is well understood. In normal female embryos, the reproductive tract is made from structures called the M�llerian ducts, which derive from early precursors of the kidneys. Sometimes this process of joining the tubes together is unsuccessful, and without the fusion of the M�llerian ducts, two uteri form.

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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Ramesh T Subramaniam
    Development of Nanocomposite Polymer Electrolytes (NCPEs) in Electric Double Layer Capacitors (EDLCs) Application
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  • Vladimir Pak
    Double Targeting as an Effective Anti-Cancer Strategy
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