In this condition, protein deposits of Alpha-synuclein called lewy bodies develop in nerve cells in brain regions involved in memory, reasoning, perception, thinking, behavior and movement. Many people with DLB experience movement symptoms such as hunched posture, rigid muscles, shuffling walk and trouble initiating movement. Lewy body dementia is the second most common kind of dementia after Alzheimer’s disease that gradually causes decline in mental ability. It may sometimes causes visual hallucination and unusual behaviors such as having conversations with deceased loved ones. It sometimes exists in pure form, or with other brain changes, including those commonly observed in Alzheimer's and Parkinson's diseases.
Lewy body disease affects over 100,000 Australians. Among the commonest types of dementia in Australia dementia with Lewy bodies counts up to 10%.
Translational toolsas applicable to autoimmune disorders: antibody-proteases as a generation of highly informative and unique biomarkersto monitor subclinical and clinical stages of demyelination in multiple sclerosis (MS) PPT Version |