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Narcolepsy

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  • Narcolepsy

    Pathophysiology
    Narcolepsy is a chronic disease of the central nervous system. Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. Other primary symptoms of narcolepsy include: loss of muscle tone (cataplexy), istorted perceptions (hypnagogic hallucinations), and inability to move or talk (sleep paralysis).

  • Narcolepsy

    Statistics
    The SART, MWT, and ESS all had good reliability, obtained for the SART and MWT using two to three sessions in 1 day. The ability to distinguish responders from nonresponders, classified using the CGI-C score, was high for all measures, with a high performance for the SART (r = 0.61) and the ESS (r = 0.54).

  • Narcolepsy

    Treatment
    1.Stimulants. Drugs that stimulate the central nervous system- modafinil or armodafinil 2.Selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs)- fluoxetine 3. Tricyclic antidepressants- protriptyline, imipramine 4.Sodium oxybate

 

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