Narcolepsy

Pathophysiology
Narcolepsy is a chronic disease of the central nervous system. Excessive daytime sleepiness (EDS) is the main symptom and is present in 100% of patients with narcolepsy. Other primary symptoms of narcolepsy include: loss of muscle tone (cataplexy), istorted perceptions (hypnagogic hallucinations), and inability to move or talk (sleep paralysis).

Statistics
The SART, MWT, and ESS all had good reliability, obtained for the SART and MWT using two to three sessions in 1 day. The ability to distinguish responders from nonresponders, classified using the CGI-C score, was high for all measures, with a high performance for the SART (r = 0.61) and the ESS (r = 0.54).

Treatment
1.Stimulants. Drugs that stimulate the central nervous system- modafinil or armodafinil 2.Selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs)- fluoxetine 3. Tricyclic antidepressants- protriptyline, imipramine 4.Sodium oxybate