Nonulcer stomach pain is a term used to describe signs and symptoms of indigestion that have no obvious cause. Nonulcer stomach pain is also called functional dyspepsia or nonulcer dyspepsia. In Australia, a prevalence of dyspepsia of 12% has been reported. The annual rate of hospitalization for NUD decreased from 205 admissions per 100,000 people to 7.7 admissions per 100,000 people. During the same period, the annual mortality rate for NUD decreased from 165 deaths per 100,000 people to 6 deaths per 100,000 people.
Treatment with medications has variable success. Some patients obtain relief from antacids or acid-suppressing drugs, and some patients with symptoms suggestive of a problem with stomach emptying may be helped by medications which increase emptying. Antacids and sucralfate were found to be no better than placebo in a literature review. H2-RAs have been shown to have marked benefit in poor quality trials (30% relative risk reduction), but only a marginal benefit in good quality trials.