Typhoid Fever

  Typhoid fever (enteric fever) is a septicaemic illness characterisedinitially by fever, bradycardia, splenomegaly, abdominal symptomsand 'rose spots' which are clusters of pink macules on the skin. Complications such as intestinal haemorrhage or perforation can develop in untreated patients or when treatment is delayed. According to health officials, incidence of typhoid fever in Australian travelers returning home have increased in recent years and failure to get vaccinations prior to travel may be to blame. Additionally, an increasing number of Australian travelers are bringing typhoid home with them, prompting a reminder for people to get pre-travel vaccinations.

 The incidence of Typhoid fever among Australian residents increased from four to five before 2003 to seven cases per million person-years after 2003. Multidrug resistance (chloramphenicol, ampicillin, trimethoprim) and nalidixic acid resistance emerged rapidly from the early 1990s, with nalidixic acid resistance increasing to 70% in 2009–2010, while multidrug resistance was relatively stable at between 4% and 11%. Researches happening on Comparative genomics study for identification of putative drug targets in Salmonella typhi Type 2, Clinical Outcome of a Portosplenomesenteric Venous Thrombosis in Necrotizing Acute Pancreatitis with Protein C and S Deficiency Treated by Anticoagulation Therapy Alone.