Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Łukasz Kraszula
II Chair of Internal Medicine,
Kopcinski 22, 90-153 Lodz
Poland
Special Issue Article
The Relationship between Leptin, Adiponectin, Resistin and FoxP3+ Treg cells in Patients with Severe Asthma
Author(s): Łukasz Kraszula, Makandjou-Ola Eusebio, Anna Jasińska, Maciej Kupczyk, Piotr Kuna and Mirosława PietruczukŁukasz Kraszula, Makandjou-Ola Eusebio, Anna Jasińska, Maciej Kupczyk, Piotr Kuna and Mirosława Pietruczuk
Objective: The aim of this study was to evaluate the relationship between selected adipocytokines and Foxp3+ Treg cells in patients with asthma.
Methods: The study included fifty-seven patients with asthma (30 with severe and 27 with mild to moderate asthma). The control group comprised 25 healthy volunteers. Asthma was diagnosed in accordance with GINA 2014 recommendation. The phenotype of CD4+CD25highCD127lowFoxp3+ cells was evaluated by multicolor flow cytometry. The concentrations of adipocytokine were determined by immunoenzymatic method (ELISA).
Results: The percentage of CD4+CD25highCD127low Treg cells expressing Foxp3+ in the patients with severe (female 76.5% (66.1-85.2), male 67% (43.5-81.2)), were significantly lower than t.. View More»
DOI:
10.4172/2155-9899.1000426