alexa Amanda C LaRue | Medical University of South Carolina
ISSN: 2572-4916

Journal of Bone Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
 
 

Amanda C LaRue

Amanda C LaRue Amanda C LaRue Associate Professor Department of Pathology & Laboratory Medicine Medical University of South Carolina USA
Biography
Dr. LaRue is the Research Health Scientist and Acting Associate Chief of Staff for Research at Ralph H. Johnson VAMC, Associate Professor Department of Pathology and Laboratory Medicine, Associate Director of Hollings Cancer Center FCCS Shared Resource at Medical University of South Carolina, USA
Research Interest

My primary research interest lies in the plasticity of hematopoietic stem cells (HSCs). Using a unique single cell HSC transplantation model, work in my laboratory addresses the role of HSCs in both pathological and physiological conditions. Current studies are directed at two major areas. The first is the examination of the role of HSCs in the development and progression of solid tumors. Our in vivo studies have demonstrated that both circulating fibroblast precursors (CFPs) and carcinoma associated fibroblasts (CAFs) are of HSC origin. We are currently investigating the roles that these HSC-derived stromal cells play in promoting tumor progression and metastasis and elucidating mechanisms regulating the cross-talk between these HSC-derived cells and tumor cells. The long-term goal of these studies is to target HSC-derived CFPs and CAFs to inhibit tumor progression. The second area of focus for my laboratory is aimed at determining the ability of HSCs to generate mesenchymal cells including adipocytes, osteocytes and chondrocytes. Our recent data from transplantation models indicate that HSCs give rise to adipocytes, osteoblasts, osteocytes and chondrocytes in vivo. Current studies are aimed at determining the participation of these HSC-derived cells in injury models such as fracture and disorders such as obesity. The ultimate goal of these studies is to develop unique avenues of therapy for diseases of mesenchymal tissues.

Publications

Global Speakers in the subject

Global Experts in the subject

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords