Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Frederick, MD, USA
Dr. Amar Klar pioneered the field of epigenetics by discovering the first gene, named MAR1/SIR2, and implicated it in the gene-silencing phenomenon in budding yeast in the late 70s. His group also discovered other gene-silencing factors, named CLR (crytic loci regulatory factors), in fission yeast. Dr. Klar also discovered the DNA strand-specific imprinting mechanism for mating-type switching in fission yeast. This unique mechanism showed that developmentally asymmetric cell division results from the double helical structure of DNA combined with replication history of DNA strands.
yeast epigenetic mechanisms,yeast genetics,etiologies of psychoses,etiology of hand-use preference,brain laterality development,visceral laterality development
Neurological Disorders received 1253 citations as per Google Scholar report
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