alexa Amarnath Natarajan | OMICS International
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
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Amarnath Natarajan

Associate professor
Eppley Institute for Research in Cancer and Allied Diseases
UNMC-Eppley Cancer Center, University of Nebraska Medical Center
985950 Nebraska Medical Center Omaha, NE 68198-5950, USA 
Biography

Dr. Amarnath Natarajan is an Associate professor in the Eppley Institute, Previously he is Assistant professor at the University of Texas Medical Branch in Galveston. He completed his Ph.D. in organic chemistry, University of Vermont, and his research interest are aims to develop chemical probes for protein-protein interactions. 

Research Interest

Phosphorylation and de-phosphorylation reactions of cellular proteins are ubiquitous in nature and represent the molecular on/off switch that triggers innumerable signaling events. Our research interest focuses on the use of small molecules to perturb these post translationally modified targets as a first step towards understanding how cells exploit these modified proteins in signal transduction. Chemical probes for this effort are derived from natural products and the design of conformationally constrained mimics. Synthetic chemistry spearheads the research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to these post translationally modified proteins. 

Publications

Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins

Hamid Band, Scott Nadeau, Wei An, Nick Palermo, Dan Feng, Gulzar Ahmad, Lin Dong, Gloria E.O. Borgstah, Amarnath Natarajan, Mayumi Naramura and Vimla Band

Review Article: Biochem Anal Biochem 2013, S6-001

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