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Dr. Ehud Banin, a returning scientist from the University of Washington, Seattle, is a Member of the Nano Cleantech Center at the Institute of Nanotechnology and Advanced Materials (BINA), and lecturer at the Mina and Everard Goodman Faculty of Life Sciences. Banin has shown how bacteria under attack by the immune system create biofilms, surface-associated bacterial communities encased in an extracellular polymeric matrix. Characterized by an innate resistance to immune system- and antibiotic-killing, microbial biofilms are a common and difficult-to-treat cause of medical infections. By revealing the specific pattern of gene expression that allows harmful bacteria to band together and survive in biofilms, Banin is defining an important target in the ongoing fight against antibiotic resistance, as well as for the search for new treatments for biofilm-related diseases such as cystic fibrosis. His laboratory implements an array of physiological, biochemical, and genetic tools combined with novel technologies that allow controlled and reproducible biofilm growth to characterize bacterial biofilms and compare them to the non-biofilm communities.
One of Banin's major objectives is to characterize how biofilms develop, with a focus on the role of iron as a signal in biofilm development. In addition, he would like to understand the mechanisms by which biofilms obtain increased resistance to antimicrobial therapy, and the role of inter- and intra-species cell-cell communication in mixed species biofilm interactions. The overriding goal of Banin's team is to discover novel compounds that effectively eradicate biofilms. Nanotechnology, Nanobiotechnology, Nanoparticles, Nanomaterial and Nanomedicine
Makarovsky Igor, Boguslavsky Yonit, Lellouche Jonathan, Banin Ehud and Lellouche Jean-Paul
Research Article: J Nanomed Nanotechnol 2012, S11-001