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Dannis van Vuurden, MD, is working as a pediatric oncologist / hematologist in VU University Medical Center (VUmc) since 2008. His specific focus, both in the clinic as in translational research, is on pediatric high-grade brain tumors, with an emphasis on pediatric high-grade glioma and DIPG. He obtained his PhD in 2014 at the VU University Amsterdam, with his thesis entitled: 'Innovative treatment targets in pediatric high-grade brain tumors', studying new targets in vitro for potential translation to the clinic. After his PhD, he combines clinical work with translational research, leading translational pediatric neuro-oncology projects, translating new therapies from the lab to the clinic. Together with the Neuro-Oncology Research Group of the VUmc Cancer Center Amsterdam, the department of clinical pharmacology and pharmacy and department of radiology & nuclear medicine of VUmc he is developing molecular imaging studies, to increase knowledge on drug delivery in pediatric brain tumor patients, by using novel agents coupled to radio-isotopes, imaged by PET. Furthermore, he is leading early phase clinical trials, such as a study of convection-enhanced intra-tumoral delivery of BiCNU in patients with progressive DIPG. He is an active member of the Novel Therapeutics Research Committee of the Dutch Childhood Oncology Group (DCOG) As chair of the DIPG Network of the International Society of Pediatric Oncology Europe (SIOPe) he has created a European DIPG Registry, which allows registration of all European DIPG patients for research and future collaborative international trials in DIPG.
Pediatric neuro-oncology Diffuse intrinsic pontine glioma
Dannis G van Vuurden, Shruti Shukla, Laurine E Wedekind, Gitta K. Kuipers, David P Noske, W Peter Vandertop, M Vincent M Lafleur, Ben J Slotman, Esther Hulleman, Gertjan JL Kaspers and Jacqueline Cloos
Research Article: J Cancer Sci Ther/Vol.5.7 249-255 (2013)
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