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Denis Loiselle | OMICS International
ISSN: 2329-9126

Journal of General Practice
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Denis Loiselle

Denis Loiselle Professor.Denis Loiselle, Department of Physiology and Auckland Bioengineering Institute, Auckland University. MSc Alta., PhD Dal., DipPhEd Otago.


Professor Loiselle completed a PhD at Dalhousie University prior to a five-year stint in the laboratory of Professor Colin Gibbs at Monash University. He joined the Department of Physiology in 1982 and is a foundation member of the Auckland Bioengineering Instutute. His interest is in the thermodynamics of muscle contraction. His research comprises the design and execution of experiments to test hypotheses concerning the mechano-energetics of cardiac muscle in both the healthy state and during various forms of heart failure. He has developed technology to measure the rate of oxygen consumption of isolated, working, whole-hearts as well as the rate of heat production of isolated tissues undergoing realistic work loops, the common metric being mechanical efficiency: the ratio of macroscopic work output to metabolic energy expenditure. Some of his Selected publications and creative works (Research Outputs) include: Han, J. C., Barrett, C. J., Taberner, A. J., & Loiselle, D. S. (2015). Does reduced myocardial efficiency in systemic hypertensive-hypertrophy correlate with increased left-ventricular wall thickness?. Hypertension research : official journal of the Japanese Society of Hypertension, 38 (8), 530-538. 10.1038/hr.2015.37 URL: University of Auckland co-authors: Andrew Taberner, Carolyn Barrett Tran, K., Loiselle, D. S., & Crampin, E. J. (2015). Regulation of cardiac cellular bioenergetics: mechanisms and consequences. Physiological reports, 3 (7). Other University of Auckland co-authors: Kenneth Tran Cheuk, M. L., Anderson, A. J., Han, J.-C., Ruddy, B. P., Ward, M.-L., Loiselle, D. S., ... Taberner, A. J. (2015). Using Optical Coherence Tomography to Measure Dynamic Changes in the Geometry of Isolated Cardiac Trabeculae during a Twitch. BIOPHYSICAL JOURNAL. (pp. 1). Other University of Auckland co-authors: Bryan Ruddy, Andrew Taberner, Marie-Louise Ward Cairns, S. P., Leader, J. P., Loiselle, D. S., Higgins, A., Lin, W., & Renaud, J. E. (2015). Extracellular Ca2+-induced force restoration in K+ depressed skeletal muscle of the mouse involves an elevation of [K+]i: implications for fatigue. J Appl Physiol (1985), 10.1152/japplphysiol.00705.2013 Han, J. C., Tran, K., Johnston, C. M., Nielsen, P. M., Barrett, C. J., Taberner, A. J., & Loiselle, D. S. (2014). Reduced mechanical efficiency in left-ventricular trabeculae of the spontaneously hypertensive rat. Physiological reports, 2 (11).10.14814/phy2.12211

Research Interest

design and execution of experiments to test hypotheses concerning the mechano-energetics of cardiac muscle