alexa Fazlul H Sarkar | Wayne State University
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Fazlul H Sarkar

Fazlul H Sarkar Departments of Pathology and Oncology
Wayne State University
USA
Biography

Dr. Sarkar is currently a Distinguished Professor, Departments of Pathology and Oncology at Karmanos Cancer Institute, Wayne State University School of Medicine. Dr. Sarkar’s early research, which still continues, is focused on understanding the role of a “master” transcription factor and the regulation of its upstream and downstream signaling molecules in solid tumors, and focusing on tumor microenvironment. Moreover, his research has been directed toward elucidating the molecular mechanism(s) of action of “natural agents”, their synthetic analogues, and other synthetic small molecule inhibitors of Bcl-2 and MDM2 for cancer prevention and therapy. The discoveries from in vitro and in vivo preclinical studies led to the design and execution of multiple Phase I/II clinical trials in breast, pancreas and prostate cancer for assessing the effects of several “natural agents” in the alterations of biomarkers as well as some early clinical efficacy testing. Dr. Sarkar’s research led to the concept of chemo-sensitization of cancer cells by reversing their drug-resistance phenotype to conventional therapeutics (chemo-radio-therapy), and all of which has been focused on tumor microenvironment, which led to clinical trials conducted at the Karmanos Cancer Institute. The innovation of his basic science research has attracted clinicians to collaborate with him, which clearly documents his leadership in translational research. Dr. Sarkar’s collaborations with basic scientists and physician scientists at MD Anderson Cancer Center led him to become a project leader for the Pancreas Cancer SPORE grant of MD Anderson Cancer Center under the leadership of Dr. James Abbruzzese, and Dr. Sarkar also served as a co-investigator for the University of Michigan Head and Neck Cancer SPORE grant.

Research Interest

cancer biology, cancer drug discovery, experimental therapeutics, medicinal chemistry, molecular mechanism of tumor

Publications

Comparative Analysis of Differentially Expressed miRNAs and their Downstream mRNAs in Ovarian Cancer and its Associated Endometriosis

Richard Licheng Wu, Shadan Ali, Sudeshna Bandyopadhyay, Baraa Alosh, Kinda Hayek, MHD Fayez Daaboul, Ira Winer, Fazlul H Sarkar and Rouba Ali-Fehmi

Research Article: J Cancer Sci Ther/Vol.7.8 258-265 (2015)

DOI: 10.4172/1948-5956.1000359

Notch Signaling Pathway in Pancreatic Cancer Progression

Jia Ma, Jun Xia, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang

Review Article: Pancreat Disorders Ther 2013, 3: 114

Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy

Irfana Muqbil, Ginny W Bao, Rkya El-Kharraj, Minjel Shah, Ramzi M Mohammad, Fazlul H Sarkar and Asfar S Azmi

Review Article: J Stem Cell Res Ther 2012, S7-005

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