alexa Gabriele Varani
ISSN: 2153-0769

Metabolomics:Open Access
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Gabriele Varani

Departments of Chemistry
University of Washington
USA
Biography
He is aProfessor of Biochemistry and Professor of Chemistry, University of Washington, USA.Raised in Italy, he received his undergraduate and doctorate degrees in physics from the Universita di Milano with Giancarlo Baldini while studying optical properties of small molecule binding to DNA. The work undertaken at the NMR provided the foundation for a commercial activity. In 1997 he and Jon Karn founded Ribotargets Ltd with venture capital support from Apax Partners and others. The goal of the company was to develop new small molecules that bind viral RNAs (HIV and Hepatitis C) and inhibit viral replication, and to find new inhibitors of protein synthesis that bind ribosomal RNA (about 40% of all existing antibiotics are ribosomal RNA inhibitors). The company now employs approximately 100 scientists and is located in Cambridge, England. In September 2001 he moved from Cambridge to the University of Washington. 
Research Interest

The Varani research group studies the interactions between proteins and nucleic acids to understand how proteins bind nucleic acids at the physical chemical level, with the aim of being able to rationally design new peptides and small molecule drugs that are able to control human regulatory networks or repress viral replication. Members of the group use spectroscopic (NMR), crystallographic, computational and biochemical techniques to achieve this goal.

Publications

Behind Every Good Metabolite there is a Great Enzyme (and perhaps a structure)

Garry W. Buchko, Isabelle Phan, Lisabeth Cron, Robin Stacy, Lance J. Stewart, Bart L. Staker, Thomas E. Edwards, Gabriele Varani, Wesley Van Voorhis and Peter J. Myler

Editorial: Metabolomics 2013, 3:e124

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