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Dr. Harsimran Kaur is an assistant professor of Biotechnology at Sri Guru Granth Sahib World University, Fatehgarh Sahib, Punjab. She has done her Masters in Microbiology. Her doctoral research under the guidance of Dr. Lalit M Bharadwaj dealt to mimic these bionanomachines (actinomyosin) and explore their capability for carrying motes in desired direction and orientation for nanorobotic application. She has been awarded Young Scientist Award by SERB-Department of Science & Technology, India in 2013. She has published 11 research articles in international journals.
My research area focuses on the design, preparation and in vitro characterization of polymeric, hydrogel nanoparticles. The goal is to formulate nanoparticles of polymers like PLGA, PVP and PAN. These nano-hybrids are further explored for their functional applications in the enlisted studies:
1. Nanoencapsulation of water soluble vitamins into biodegradable polymer for sustainable release. The approach is to protect bioactive molecules (vitamins, antioxidants, proteins, and lipids as well as carbohydrates) by enveloping them with a biodegradable shell.
2. Enhancing delivery of drug by attaching ligands selectively to internalizing antigens. It would help to increase the concentration of drugs inside tumor or tumor-associated endothelial cells resulting in higher drug concentration inside the cell and greater destruction or inhibition of tumor cells. Research study will focus on delivery of breast cancer drugs.
3. Research is focused on isolation of microorganisms synthesizing nanoparticles and characterization of synthesized nanoparticles from microorganisms under stress condition from metal contaminated soil. The development of eco-friendly technologies in nanoparticles synthesis is of considerable importance to expand their biological applications. These biosynthesized nanoparticles can be explored in biomedical sciences and environment bioremediation.
4. Encapsulation of bactericidal drugs in polymeric nanogels can enhance the availability of drugs for a longer duration. These polymeric nanogels will lead to sustainable release of encapsulated drugs. The aim of this project is to study the bactericidal efficacy of nanogel encapsulated antibiotic against gram negative and gram positive bacteria
Harsimran Kaur and Arun Sharma
Mini Review: Biosens J 2015, 4: 131