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Shimokawa is Professor and the Chairman of the Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Dr. Shimokawa graduated from Kyushu University in 1979, obtained PhD degree in 1985, and has been appointed for the present position in 2005. His research projects include (1) molecular mechanisms of coronary artery spasm and atherosclerosis, (2) endothelial function, (3) development of innovative medical therapies, and (4) large clinical trials of heart failure and ischemic heart disease. He is well known for the development of animal models of coronary spasm and the identification of endothelium-derived hydrogen peroxide as an important endothelium-derived relaxing factor. He is also the pioneer for the development of extracorporeal cardiac shock wave therapy for the treatment of severe angina pectoris. He has published more than 500 peer-reviewed papers in the leading journals, such as Science, The Lancet, The Journal of Clinical Investigation, Circulation, The Journal of the American College of Cardiology, European Heart Journal, Circulation Research, and ATVB. He received the Satoh Award (the Society Award) of the Japanese Circulation Society (JCS) in 1999, the Jeffrey M. Hoeg Award of the American Heart Association (AHA) in 2006, the Japan Medical Association Award in 2012, and the William Harvey Lecture Award of the European Society of Cardiology (ESC) in 2014. He now serves as the Editor-in-Chief of Circulation Journal (JCS) as well as an Associate Editor of European Heart Journal (ESC) and ATVB (AHA) and a Senior Consulting Editor of Circulation Research (AHA), in addition to the editorial board members of many international journals, including Circulation and American Journal of Physiology. He also serves as the president of the Japanese Society for Gender-specific Medicine, the Nitric Oxide Society of Japan and the Japanese Pulmonary Circulation Society, in addition to the board members of the Japanese Circulation Society, the Japanese College of Cardiology, the Japanese Heart Failure Society, the Japanese Society for Cardiovascular Research, the Japanese College of Angiology, the Japanese Association of Cardiac rehabilitation, etc. He also is a Fellow of the American Heart Association (AHA) and the European Society of Cardiology (ESC).
Arteriosclerotic vascular disease; Nitric oxide synthase; Knockout mice; Transgenic mice; Myocardial infarction