Mycobacterial Diseases
Open Access

Ian M Orme

Biography

Dr. Ian M Orme is Professor of Colorado State University. His continuing objective is to develop relevant small animal models of tuberculosis, the world’s most devastating bacterial disease. Over the past decade his major contributions to understanding the basis of the pulmonary immune response to tuberculosis, using diverse technologies ranging from advanced flow cytometry to the use of mice in which specific genes have been selectively disrupted [gene-knockout mice]. In the guinea pig model, an animal that exhibits lung pathology very similar to that seen in humans infected with tuberculosis, they have systematically described the course of the infection using standard histology, immunohistochemistry, and magnetic resonance imaging. His laboratory is first to demonstrate the T cell mediated immune response in the lungs, using breakthrough flow cytometry.

Research Interest

T cell mediated immune response in the lungs, using breakthrough flow cytometry and Tuberculosis

Relevant Topics