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Jeroen J. J. P. van den Beucken | OMICS International
ISSN:2090-5025

Bioceramics Development and Applications
Open Access

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Jeroen J. J. P. van den Beucken

Jeroen J. J. P. van den Beucken Department of Biomaterials,
Radboud University Nijmegen Medical Center,
Nijmegen,
The Netherlands

Biography

My scientific career has focused on the interaction of materials with tissue; more specifically on (i) how cells and tissues respond to material surfaces with different properties, and (ii) how to optimize material degradation and tissue formation for the regeneration/augmentation of bone tissue. Within the interdisciplinary field of biomaterials, I have significantly increased my expertise from both a material and a biological point of view using a plethora of techniques for material characterization and analysis of the biological response by cells (in vitro) and tissues (in vivo). In view of the three key elements for tissue engineering and regenerative medicine, I worked on material properties, surface modification, and (growth factor) release systems for optimisation of material performance. Alternatively, I focussed on cell-based strategies for bone regeneration using adult mesenchymal stem cells for bone formation either or not combined with angiogenic cells to stimulate vascularisation. For the in vitro evaluation of material performance, I used adult stem cell cultures, leukocyte cultures, and endothelial cell cultures, whereas in vivo evaluation relied on 2-dimensional and 3-dimensional techniques in the form of histology, histomorphometry, and micro-computed tomography as well as gene expression for specimens harvested from healthy and compromised animal models.

Research Interest

Biomaterials, Intrinsic properties, Animal models, Drug release, Cell-based bone regeneration

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