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My research focus is in the area of oncology, with particular emphasis on immune regulation in patients with squamous cell carcinoma of the head and neck (HNSCC). Immunotherapy for cancer patients is a treatment approach that has been the thrust of my studies. However, stimulation of anti-cancer immune reactivity is hampered by the severe immune dysfunction in cancer patients. The studies in my laboratory have identified several mechanisms to overcome this immune dysfunction so that subsequent immune vaccines can be effective. Toward this goal, my basic science laboratory studies have progressed into several clinical trials with HNSCC patients. I have been an independent PI for more than 25 years with national, peer-reviewed funding from VA, NIH, DOD, and others.
Research Article: J Clin Cell Immunol 2014, 5: 230