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ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Mary C Dinauer

 Departments of Pediatrics (Hematology/Oncology), Microbiology/Immunology, and Medical and Molecular Genetics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
Biography

 Mary C Dinaueris distinguished Chair in Pediatric Research Professor of Pediatrics and of Pathology and Immunology Scientific Director, Children’s Discovery Institute. Her present research on the leukocyte NADPH oxidase and the role of oxidant production by neutrophils and macrophages in microbial killing, the inflammatory response and regulation of adaptive immunity. Other studies focus on the development of gene replacement therapy for X-linked CGD, utilizing viral vectors to introduce the corrective gene into murine and human hematopoietic stem cells, and novel conditioning strategies for marrow transplantation. These questions are being studied using a combination of molecular and cell biology approaches and animal models, including mice generated by gene targeting

Research Interest

 Hematology, Oncology, Developmental Biology, Immunology,Adaptive immunity,Gene replacement therapy,stem cells

Publications

Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox

Dirk Roos, Jaap D van Buul, Anton TJ Tool, Juan D Matute, Christophe M Marchal, Bu’Hussain Hayee, M Yavuz Köker, Martin de Boer, Karin van Leeuwen, Anthony W Segal, Edgar Pick and Mary C Dinauer

Research Article: J Clin Cell Immunol 2014, 5: 231

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