Mohammad Saeid Hejazi
Biography
1999-2002: PhD in Molecular Medicine, with a thesis entitled “Cytoplasmic Fusagene Vectors” under the supervision of Prof. Farzin Farzaneh and Dr Joop Gäken. In this study a novel approach was developed to discover new and/or tissue specific cytoplasmic and possibly nuclear proteases. Proteases play a key role in cell physiology. They are involved in protein maturation, activation and processing. Therefore, they can be employed in processing of therapeutic proteins or other applications. For instance, recently furin endoprotease has been exploited to express secretary (e.g. IL-2, IL-4) and transmembrane molecules (e.g. B7.1) from a single cistron (i.e. a single expression vector). Therefore, identifying the tissue specific endoproteases, which cleave the specific sequences, will help to better understand cell biology and use them in different protocols.1998-1999: MSc in Immunology. Conducted research and presented a thesis entitled “Development of Tumour Cell Vaccination for Acute Myeloid Leukaemia (a murine model)” in AML immunogene therapy field under the supervision of Prof. Farzin Farzaneh. In this study IL-2/B7.1 and GFP encoding viruses were produced. Then IL-2 and B7.1 were expressed in AML cells and measured as secretory and transmembrane proteins by FACS and ELISA, respectively. The infected cells were irradiated and in mixed lymphocyte reaction –MLR- their ability to stimulate T cells proliferation was examined.1984-1990: Pharm.D; Doctorate of pharmacy from Faculty of Pharmacy at Tabriz University of Medical Sciences. Conducted research and presented a thesis entitled “Formulation of nalidixic acid suspension” under the supervision of Prof. Barzegar Jalali. In this study different controlled flocculation protocols including chemical bridge, polymeric bridge, zeta potential reduction and liquid bridge methods were used to make stable suspensions. In addition, non-newtonian carriers were used to make stable suspensions.Present he is Full-time professor at Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences
Research Interest
Discovery of a novel bacterial genus called Tabrizicola aquatica. The corresponding article is published in Antonie van Leeuwenhoek journal as “Tabrizicola aquatica gen. nov. sp. nov., a novel alphaproteobacterium isolated from Qurugöl Lake nearby Tabriz city, Iran”.
Discovery of a novel bacterial species called Alishewanella tabrizica. The corresponding article is published in International Journal of Systematic and Evolutionary Microbiology as “Alishewanella tabrizica sp. nov., isolated from Qurugöl Lake in mountainous region of Azerbaijan at northwest of Iran
