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have spent over 38 years in the research on Infectious diseases. During this period I had an opportunity to work in two ICMR Institutes, National Institute for Tuberculosis Research, from 1976 to 1993 and National AIDS Research Institute from 1993 onwards. Early during the career I worked on immune responses in Human filariasis. The work resulted in identifying allergic response to filarial antigens as an etiology of tropical pulmonary eosinophilia. A circulating filarial antigen was identified and purified; and a monoclonal antibody based assay was developed for the detection of filarial antigen. After a short time spent in understanding immune responses in tuberculosis patients I have spent last two decades in HIV research. Establishing the specialty laboratories and a team of multiâdisciplinary research scientists was priority to kick start the activities of this new Institutes. Besides supporting various Institutional activities I personally developed immunology programme, vaccine research programme and antiâHIV drug development programme at NARI. In the last decade and a half I provided the leadership for the Institute. During this period the Institute assumed leadership in a number of research areas such as clinical research for HIV prevention and treatment, women controlled methods for HIV prevention, HIV and HPV infection, HIV and TB coâinfections, HIV biology, HIV drug resistance testing etc. During this period NARI has forged a close alliance with National AIDS Control Programme and NARI plays a major role in quality control and surveillance studies besides involving in human resource development, developing guidelines and manuals and providing technical inputs. As the Director of NARI, I have been instrumental in promoting research in different areas for prevention of HIV, treatment and care of HIV infected and HIV biology. The Institute established a large number of collaborations, both nationally and internationally during my two decades at NARI. I also promoted close linkages between NARI and National AIDS Control Programme.
ï»¿HIV, STI Prevention, Immunopathogenesis of HIV infection, HIV drug resistance
Karikalan Nagarajan, Seema Sahay, Deepika Ganju and Ramesh S Paranjape
Research Article: J AIDS Clin Res 2015, 6: 509
Karikalan Nagarajan, Sheela Godbole, Lakshmi Ramakrishnan, Mandar K. Mainkar, Sowmya Ramesh, Deepika Ganju and Ramesh S Paranjape
Research Article: J AIDS Clin Res 2013, 4: 212