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Robert Veerhuis heads a neuroinflammation research group at the departments of Clinical Chemistry, Psychiatry, Pathology and Alzheimer center of the VU University medical center (VUmc). His PhD study at Leiden University was devoted to the role of the complement system in the clearance of immune complexes in autoimmune diseases. After a period in veterinary research, he started studying the neuroimmunological aspects of Alzheimer’s disease and related neurodegenerative diseases at the VUmc. He is an expert in the role of glial cells in the pathogenesis of AD and related disorders, and studies neuroinflammatory and glial cell changes in post mortem human brain tissue and adult human glial cell cultures. Using these model systems he participated in EU-funded projects on glial cells in prion disease and selection and testing potential therapeutic compounds for prion diseases in biochemical assays and human cell culture models. Recent pathogenesis-related work focuses on the role of microglia and astrocytes in the clearance of misfolded proteins, especially different aggregation forms of Abeta and the effects of amyloid associated factors hereon. Another line of research concerns identifying biomarkers (with focus on amyloid associated factors including complement factors and apolipoproteins in CSF and plasma) for early diagnosis and monitoring drug treatment of neurodegenerative diseases.
Clinical Chemistry, Psychiatry, Pathology, Alzheime, veterinary research, Neuroimmunological Disorders
Research Article: J Clin Cell Immunol 2014, 5: 243