alexa Thierry Brigaud | OMICS International
ISSN: 2161-0444

Medicinal Chemistry
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Thierry Brigaud

 Department of Chemistry, Professor - Director of laboratory of organic chemistry, Université de Cergy-Pontoise, France  

Biography

Thierry Brigaud is a Professor - Director of laboratory of organic chemistry, Université de Cergy-Pontoise, France.

  • 1990:  PhD from the Claude Bernard University of Lyon I in the direction of Professor E. Lawrence.
  • 1990-1991: Post-Doc at The State University of New York at Stony Brook (USA) in the group of Prof. I. Ojima
  • 1991-2002: Lecturer at the University of Reims Champagne-Ardenne
  • Since 2002: Professor at Cergy-Pontoise University
  • Since 2012: Director of the Research Unit SOSCo (now LCB)

 

Research Interest

 Use oxazolidines trifluorométhylées (Fox) as chiral auxiliaries in asymmetric synthesis. Fluorinated building blocks chiral synthesis (amino acids, amino alcohols, diamines) from fluorinated oxazolidines (Fox). Development of new peptide coupling methods for the incorporation of α-amino-α-trifluoromethylated in peptide chains. Application to the synthesis of peptides of interest (peptaibols, peptides targeting the CNS mimics collagen, ...). Study of conformational constraints induced by the incorporation of pseudoprolines trifluorométhylées in peptide chains. Study of physico-chemical and biochemical properties of trifluoromethylated peptides (lipophilicity, pKa, protease resistance).

Publications

Effects of Enantiopure (S)-a-Trifluoromethyl Proline Containing MIF-1`s Analogue on Stress-induced Analgesia

Adriana Bocheva, Hristina Nocheva, Ibtissem Jlalia, Nathalie Lensen, Grégory Chaume and Thierry Brigaud

Research Article: Med Chem (Los Angeles) 2013, 3: 206

DOI: 10.4172/2161-0444.1000140

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