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Thierry Brigaud is a Professor - Director of laboratory of organic chemistry, Université de Cergy-Pontoise, France.
Use oxazolidines trifluorométhylées (Fox) as chiral auxiliaries in asymmetric synthesis. Fluorinated building blocks chiral synthesis (amino acids, amino alcohols, diamines) from fluorinated oxazolidines (Fox). Development of new peptide coupling methods for the incorporation of α-amino-α-trifluoromethylated in peptide chains. Application to the synthesis of peptides of interest (peptaibols, peptides targeting the CNS mimics collagen, ...). Study of conformational constraints induced by the incorporation of pseudoprolines trifluorométhylées in peptide chains. Study of physico-chemical and biochemical properties of trifluoromethylated peptides (lipophilicity, pKa, protease resistance).
Adriana Bocheva, Hristina Nocheva, Ibtissem Jlalia, Nathalie Lensen, Grégory Chaume and Thierry Brigaud
Research Article: Med Chem (Los Angeles) 2013, 3: 206