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Dr. Nolin is an Assistant Professor in the School of Pharmacy, Department of Pharmacy and Therapeutics, and holds a secondary appointment in the Department of Medicine Renal Electrolyte Division. He received his BS in Pharmacy from the University of Connecticut, and then completed a residency and MS in Hospital Pharmacy from the University of North Carolina at Chapel Hill. After working for several years as a clinical pharmacy specialist in nephrology and transplantation at Maine Medical Center (MMC) in Portland, Maine, Dr. Nolin matriculated to the University of Pittsburgh where he received a PharmD and a PhD in Clinical Pharmaceutical Sciences with concentration in drug metabolism/pharmacokinetics. Dr. Nolin returned to MMC upon completion of his PhD in 2003, where he was a clinical pharmacologist in the Division of Nephrology and Transplantation, a principal investigator in the Center for Clinical and Translational Research at the Maine Medical Center Research Institute, and an Assistant Professor of Medicine at the University of Vermont College of Medicine. He joined the faculty at the University of Pittsburgh in 2008.
Dr. Nolin's research interests include evaluation of the functional expression of drug metabolizing enzymes and transporters in humans, clinical pharmacokinetics in kidney disease, including assessment of PK during renal replacement therapy, and the development of novel analytical techniques. His primary research focuses on studying the impact of kidney disease on pathways of nonrenal drug clearance, particularly those mediated by cytochrome P450 enzymes and P-glycoprotein and organic anion transporting polypeptide transporters, as well as identifying mechanisms by which kidney disease contributes to alterations in these elimination pathways.