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Dr. Uri Barash is a postdoctoral fellow in the group of Prof. Israel Vlodavsky at the Cancer & Vascular Biology Research Center of the Technion. He performed his MSc research under the supervision of Prof. R. Kaempfer (Hebrew University) and Ph.D. thesis under the supervision of Prof. I. Vlodavsky (Technion). The main achievement of his PhD research is the identification of a truncated heparanase splice variant (termed T5) lacking enzymatic activity, but still possessing pro-tumorigenic and pro-angiogenic properties, thereby emphasizing the significance of heparanase non-enzymatic activities. Recently, Uri identified a novel mechanism by which heparanase facilitates myeloma tumor progression through down regulation of CXCL10, possibly offering a new treatment modality for this disease.
Cancer Biology, Immunotherapy
Research Article: J Clin Cell Immunol 2015, 6: 290