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Dr. Jun Lin is working in Department of Animal Science in theThe University of Tennessee 2640 Morgan Circle Drive, Knoxville, USA.His research program is primarily focused on molecular mechanisms of bacterial pathogenesis and drug resistance, which would reveal potential targets for development of novel intervention strategies and diagnostic tools against pathogens important in animal health and food safety. In addition, he have long-term interest in intestinal microbiota with emphasis on the discovery of microbiome target for enhanced animal production and human health. Specifically, in the past, he have used fundamental and contemporary approaches to study Campylobacter jejuni, the leading foodborne human pathogen causing enteritis in the United States and many other industrialized countries. Given that poultry are the major reservoir of C. jejuni, on-farm control of C. jejuni is urgently needed to reduce human exposure and the number of foodborne illness in the U.S. To this end, we have established following four identifiable research programs: 1) High-affinity iron acquisition in Campylobacter; 2) Development and evaluation of novel Campylobacter vaccines; 3) Molecular basis and regulation of antimicrobial peptide resistance in Campylobacter; and 4) Beta-lactam resistance mechanisms in Campylobacter. In addition, he also successfully established a collaborative and multidisciplinary research program focused on the effect of antibiotic growth promoter on intestinal microbiota using chicken model, which ultimately may lead to novel “One Health” measure for enhanced animal production, food safety, and human health.
Molecular biology, cell biologgy, microbiology, vaccines, immunology, animal sciences
Ximin Zeng, Fuzhou Xu and Jun Lin
Research Article: J Vaccines Vaccin 2010, 1:112