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Shahein received Ph.D in Biochemistry and Molecular Biology from Cordoba University (Spain) then; he joined Toronto University (Canada) as a postdoctoral scientist. He is currently an associate professor in the department of molecular biology at the National Research centre, Egypt. His research concerns with the production of recombinant vaccines against ticks. He has cloned several genes that may play a role in the vector-host relationship. Dr Shahein had constructed two cDNA libraries for both cattle and camel local hard tick strains; Rhipicephalus annulatus and Hyalomma dromedarii, respectively. Dr Shahein received research grants from MUCIA (University of Illinois, USA-2005-2007), ASTF (United Arab of Emirates-2007-2009), and KACST (Kingdom of Saudi Arabia-2010-2014).
Shahein started his postdoctoral research studying the apoptotic pathways downstream of the tumor suppressor retinoblastoma (Rb) in KO mouse. The ongoing research theme of Dr Shahein focuses on molecular cloning and gene expression of tick genes infesting cattle and camels in Egypt and Middle East. He produced recombinant proteins from several cloned genes as potential anti-tick vaccines.