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Abel Arul Nathan
Abel Arul Nathan
India
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Research Article
In-vitro Evaluation of Thymol Derived from Trachyspermum ammi against Acetaminophen Induced Hepatotoxicity Towards Lymphatic Filariasis Therapeutics
Author(s): Abel Arul Nathan and Anand Setty BalakrishnanAbel Arul Nathan and Anand Setty Balakrishnan
Individuals with lymphatic filariasis (LF) shows elevated levels of pro-inflammatory cytokines, altered expressions of inflammatory genes and are prone to secondary bacterial infection. Also markers of liver dysfunction were reported to be high with increased filarial infection. Acetaminophen (Paracetamol), an anti-pyretic drug was prescribed to LF individuals along with Diethylcarbamazine and Albendazole to alleviate pain and filarial fever within the therapeutic dosage. It is unclear, whether parasite secreted toxins augments the action of acetaminophen and enhances liver dysfunction. Hence, an agent which can attenuate the acetaminophen toxicity during filarial infection is warranted. Trachyspermum ammi (T. ammi) is the richest source of thymol, reported to have anti-filarial lead molecule. In the present study we evaluated the effects of thymol against acetaminophen induced hepato.. View More»
DOI: 10.4172/2155-9597.1000322