Achuthan Sourianarayanane
Tanzania
Research Article
Diabetes Mellitus, Insulin, Sulfonylurea and Advanced Fibrosis in Non-Alcoholic Fatty Liver Disease
Author(s): George Boon-Bee Goh, Mangesh R Pagadala, Jaividhya Dasarathy, Aynur Unalp-Arida, Ruth Sargent, Carol Hawkins, Achuthan Sourianarayanane, Amer Khiyami, Lisa Yerian, Rish K Pai, Srinivasan Dasarathy and Arthur J McCulloughGeorge Boon-Bee Goh, Mangesh R Pagadala, Jaividhya Dasarathy, Aynur Unalp-Arida, Ruth Sargent, Carol Hawkins, Achuthan Sourianarayanane, Amer Khiyami, Lisa Yerian, Rish K Pai, Srinivasan Dasarathy and Arthur J McCullough
Background & aims: Diabetes mellitus is a risk factor for advanced fibrosis in non-alcoholic fatty liver disease. However, not all non-alcoholic fatty liver disease patients with diabetes develop advanced fibrosis. We hypothesised that prescription medications used by these patients influence the development of advanced fibrosis. We investigated the association of commonly used medications and advanced fibrosis in non-alcoholic fatty liver disease patients with diabetes.
Methods: Clinical information including demographics, medical history, medication history, biochemical and histologic variables were ascertained in 459 patients with biopsy proven non-alcoholic fatty liver disease. We compared characteristics of patients with and without diabetes and explored potential associations between classes of drugs as risk factors and advanced fi.. View More»
