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Journal of Hematology & Thromboembolic Diseases

Journal of Hematology & Thromboembolic Diseases
Open Access

ISSN: 2329-8790

+44 1478 350008

Ahmad Reza Rahnemoon

Ahmad Reza Rahnemoon
Allied Medical School,
Tehran
West Indies

Publications
  • Review Article
    The Importance of Altered Hematopoietic Microenvironmental Regulation in Chronic Myeloproliferative Disorders
    Author(s): Ahmad Reza RahnemoonAhmad Reza Rahnemoon

    Normal hematopoiesis depends on critical interactions that occur between stem cells and their microenvironment. This microenvironment is a complex meshwork composed of growth factors, stromal cells, and the extracellular matrix. Pluripotent Stem Cells (PSCs) are the stem cells which present in Chronic Myeloproliferative Disorders (CMPD) to have self-renewal capacity and towards differentiated cells in blood cells lineages. When the process of these stem cells become deregulated, neoplasm can result with possibly several mutations as well as the alterations in the control of growth factors and meanwhile disrupt the normal HSC function and blood cell production. Thus, these interactions must important in the pathogenesis and clinical expression of hematopoietic malignancies in humans. Here, I review the leukemic hematopoietic microenvironment and the genetic alterations as well... View More»
    DOI: 10.4172/2329-8790.1000272

    Abstract PDF

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