Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
+44 1478 350008
ISSN: 2576-1447
+44 1478 350008
Ahmed M Kabel
Department of Pharmacology, Tanta
Egypt
Research Article
Ameliorative Potential of Tamoxifen/Thymoquinone Combination in Patients with Breast Cancer: A Biochemical and Immunohistochemical Study
Author(s): Ahmed M Kabel, Mohamed A El-Rashidy and Mohamed S OmarAhmed M Kabel, Mohamed A El-Rashidy and Mohamed S Omar
Background: Breast cancer is one of the most common types of malignancies in females worldwide. Targeting the estrogen receptors alone with tamoxifen, reduces the incidence of estrogen receptor positive tumors but the possibility of development of tamoxifen resistance remains the most important adverse effect. Thymoquinone is an important constituent of the Nigella sativa plant (Black seed). It was found to be cytotoxic in several types of multidrug resistant human tumor cell lines.
Objective: To detect the effects of the combination between tamoxifen and thymoquinone in patients with breast cancer.
Methods: Eighty female patients with breast cancer were divided into four equal groups: control untreated group, tamoxifen treated group, thymoquinone treated group and tamoxifen + thymoquinone treated group. Tissue malondial.. View More»
DOI:
10.4172/2576-1447.1000102