Journal of Research and Development
Open Access
ISSN: 2311-3278
ISSN: 2311-3278
Alexander E Berezin
Ukraine
Research Article
Circulating Osteoprotegerin as Predictor of Global Systolic Dysfunction in Type Two Diabetes Patients with Chronic Heart Failure
Author(s): Alexander E Berezin, Kremzer AA and Samura TAAlexander E Berezin, Kremzer AA and Samura TA
Background: Biomechanical stress and inflammatory biomarkers relate to global contractility dysfunction, however, adding these biomarkers into a risk model constructed on clinical data does not improve its prediction value in chronic heart failure (CHF).
Objectives: The aim of this study was to evaluate the interrelationship between left ventricular global contractility function and circulating biomarkers in diabetic patients with ischemia-induced CHF.
Patients and methods: The study retrospectively selected 54 T2DM subjects from 388 patients who had systolic or diastolic ischemia-induced CHF, that was defined as left-ventricular ejection fraction ≤ 45% or 46-55% respectively assessed by quantitative echocardiography and other conventional criteria according to current clinical guidelines. Two-dimensional transth.. View More»