Fungal Genomics & Biology
Open Access

Ali A

Publications

• Research Article
  Acetylcholine Induces Yeast to Hyphal Form Transition in Candida albicans
  Author(s): Ali A and Karuppayil SMAli A and Karuppayil SM
  
  Background: In Candida albicans, yeast to hyphal form transition can be induced by serum, proline, glucose, and N-acetylglucosamine. Acetylcholine is a neuromodulator which can stimulate both muscarinic and nicotinic acetylcholine receptors in humans. In this study, we are reporting that acetylcholine can induce yeast to hyphal form transition in C. albicans. The adenylyl cyclase inhibitor, MDL 12, 330A inhibited this transition indicating the role of cAMP. Muscarinic receptors in C. albicans did not report yet. We have reported that C. albicans Rrp9 exhibits identity and similarity with the human muscarinic receptor M1. In humans, activation of muscarinic M1 receptor can produce cAMP through inositol phosphate pathway. The inositol phosphate pathway in C. albicans is already known. We have carried out the local and global alignment sequences between the proteins of humans and C. albi.. View More»
  DOI: 10.4172/2165-8056.1000154

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