Journal of Animal Health and Behavioural Science

Amal A El-Daly

Publications

• Research Article
  The Histopathological, Ultrastructural and Immunohistochemical Effects of Intraperitoneal Injection with Titanium Dioxide Nanoparticles and Titanium Dioxide Bulk on the Liver of the Albino Mice
  Author(s): Amal A El-DalyAmal A El-Daly
  
  Titanium Dioxide Nanoparticles (TiO2-NPs) applications are widely used in the daily life and their potential toxicity to the living organism is necessary to be insured. The nanomaterial may or may not exhibit the same toxic potential as the original material. Therefore, this study used TiO2-NPs and their original bulk to ensure their safety on the histology, immunohistochemistry and ultrastructure of the liver of male albino mice (Mus musculus). For this purpose, 25 and 50 mg/kg b.wt.; 55 μm size; anatase TiO2-NPs compared with 50 mg/kg b.wt.; 106 μm size; anatase TiO2 micro-sized (bulk form) were daily injected intraperitoneally into the mice for ten successive days. The results showed numerous alterations in the liver of anatase TiO2-NPs treated animals in a dose-dependent manner that were more than these shown in anatase TiO2-bulk material. However, histopathological.. Read More»
  

  Abstract PDF