Hershey, PA
Tanzania
Research Article
Genetic and Demographic Correlates of Quality of Life after Ileal Pouch Anal Anastomosis for Ulcerative Colitis
Author(s): Tara M Connelly, Bailey Sanders, Arthur S Berg, Emmanuelle Williams, Leonard Harris III, Andrew Tinsley and Walter A KoltunTara M Connelly, Bailey Sanders, Arthur S Berg, Emmanuelle Williams, Leonard Harris III, Andrew Tinsley and Walter A Koltun
Objective: Patient satisfaction after ileal pouch anal anastomosis (IPAA) for ulcerative colitis (UC) is difficult to predict preoperatively and has never been investigated from a genetic perspective. Methods: Modified IBD quality of life (QOL) questionnaires were mailed to all UC-IPAA patients in our IBD Biobank. Genotyping was performed using a custom microarray containing 325 IBD-associated single nucleotide polymorphisms (SNPs). Fisher's exact and Mann-Whitney tests and logistic regression with the Bonferroni correction were used for analysis. Results: Response rate was 69% (142 of 206 patients, mean pouch duration=10.1 ± 0.5years). Patients diagnosed at a younger age and with shorter time to colectomy reported poorer emotional wellbeing scores. Readmission post-colectomy was significantly associated with poor overall and emotional scores. On multivariate analysis, female g.. Read More»
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