Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Antonio Bascones-Martinez
Faculty of Dentistry,
Spain, Pza Ramon y Cajal s / n, 28040, Madrid
Spain
Research Article
Oral Manifestations of Pemphigus Vulgaris: Clinical Presentation, Differential Diagnosis and Management
Author(s): Antonio Bascones-Martinez, Marta Munoz-Corcuera, Cristina Bascones-Ilundain and German Esparza-GómezAntonio Bascones-Martinez, Marta Munoz-Corcuera, Cristina Bascones-Ilundain and German Esparza-Gómez
Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease characterized by the formation of intraepithelial blisters. It results from an autoimmune process in which antibodies are produced against desmoglein 1 and desmoglein 3, normal components of the cell membrane of keratinocytes. The first manifestations of pemphigus vulgaris appear in the oral mucosa in the majority of patients, followed at a later date by cutaneous lesions. The diagnosis is based on clinical findings and laboratory analyses, and it is usually treated by the combined administration of corticosteroids and immunosuppressants. Detection of the oral lesions can result in an earlier diagnosis. We review the oral manifestations of pemphigus vulgaris as well as the differential diagnosis, treatment, and prognosis of oral lesions in this uncommon disease.
.. View More»
DOI:
10.4172/2155-9554.1000112