Advancements in Genetic Engineering
Open Access
ISSN: 2169-0111
+44 1478 350008
ISSN: 2169-0111
+44 1478 350008
Arnab Banerjee
Serampore College,
Serampore, Hooghly-712201, West Bengal
India
Review Article
Slit/Robo Pathway - Neurogenesis to Cancer Progression: A Potential Therapeutic Target
Author(s): Arnab Banerjee, Sreeparna Banerjee, Debasmita Das, Bithin Kumar Maji and Sandip MukherjeeArnab Banerjee, Sreeparna Banerjee, Debasmita Das, Bithin Kumar Maji and Sandip Mukherjee
Slit-Robo could be a cell signaling pathway with numerous functions such as axon steering and ontogenesis. Slit is a secreted macromolecule and most generally referred to as a repulsive axon steering cue, and Robo as its trans-membrane macromolecular receptor. This ligand-receptor combination has been concerned in different kind of neuronal and non-neuronal processes starting from cell migration to ontogenesis, tumorigenesis and organogenesis like kidneys, lungs and breasts, etc.
Roundabout receptors (Robo) and their Slit ligands were detected in axon steering. Slit was primarily associate degree extracellular matrix super molecule and expressed by plane interstitial tissue in fruit fly. Slits acted as chemorepellents for axons crossing the plane in vertebrates and invertebrates. The origin of Robo proteins were from fruit fly in an exceedingly mutant screening for genes con.. View More»
DOI:
10.4172/2169-0111.1000157