Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Azaria Amelia Adam
Indonesia
Research Article
Homocysteine, Folic Acid, Vitamin B6, Vitamin B12, and Biochemical Parameters of Bone Metabolism in Female Patients with Systemic Lupus Erythematosus
Author(s): Kusworini Handono, Tita Luthfia Sari and Azaria Amelia AdamKusworini Handono, Tita Luthfia Sari and Azaria Amelia Adam
Objectives: Premature osteoporosis is one of the long term complications of Systemic Lupus Erythematosus (SLE). Recent studies showed that increased level of homocysteine was detected in SLE patients and it was associated with deterioration of bone health. The aim of this study was to determine the association between homocysteine and biochemical parameters of bone metabolism in SLE patients.Subjects and methods: Thirty-nine female patients who fulfilled American College of Rheumatology 1997 criteria for SLE under 50 years old and twelve healthy female as control group were studied. Various laboratory parameters including serum homocysteine, folic acid, vitamin B6, vitamin B12, bCTx, osteocalcin, MDA, and RANKL were measured.Results: This study found that significantly higher levels of homocysteine were found in SLE patien.. View More»
DOI:
10.4172/2155-9899.1000217