Gene Technology

Bo Zhang

Publications

• Review Article
  Bruton's Tyrosine Kinase: Structure and Functions, Expression and Mutations
  Author(s): Ying Liu, Guang-biao Zhou, Bo Zhang and Yong-qiang LiuYing Liu, Guang-biao Zhou, Bo Zhang and Yong-qiang Liu
  
  Bruton’s tyrosine kinase (BTK), a member of the Tec family of protein tyrosine kinases (PTKs), plays a vital and diverse function in many cellular processes. BTK is expressed throughout B cell development, widely participating in multiple signal pathways including PI3K, PLCγ, and PKC. Those pathways play critical functions in cell proliferation, development, differentiation, survival, and apoptosis. The expression of BTK is selectively down-regulated in T lymphocytes and plasma cells and the relative level of BTK expression may be modulated in different developmental populations of B cells. Mutations in the gene for BTK are responsible for X-linked agammaglobulinemia (XLA) in human and X-inked immunodeficiency (xid) in mice. Both of these diseases are characterized by blocks in B-cell development at multiple stages and impaired function of residual mature B cells. To date,.. View More»
  DOI: 10.4172/2329-6682.1000106

  Abstract PDF