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Bozzetti C | OMICS International

Journal of Molecular Biomarkers & Diagnosis
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Bozzetti C


Notch Activation Modulates Bevacizumab Activity by CD44 Positive Cancer Stem Cells in Advanced Colon Cancer

Background: Notch pathway is involved in regulating colon cancer stem cells (CSCs), which play an important role in angiogenesis and resistance to conventional therapies. CD44 and CD133 are transmembrane glycoproteins reported as putative markers for isolating CSCs. High expression of Notch Intracellular Cleaved Domain (NICD) has been associated wi... Read More»

Negri FV, Bozzetti C, Pedrazzi G, Azzoni C, Bottarelli L, Squadrilli A, Lagrasta C, Tamagnini I, Bisagni A, Ragazzi M, Madeddu D, Falco A, Gervasi A, Porzio R, Tomasello G, Leonardi F, Ardizzoni A, Sala R, Gnetti L, Crafa P, Quaini F and Cascinu S

Research Article: J Mol Biomark Diagn 2017, 8:S2-036

DOI: 10.4172/2155-9929.S2-036

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